Related Experiment Video
Updated: Aug 19, 2025

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
Published on: April 21, 2022
N1-methyladenosine modification in cancer biology: Current status and future perspectives
Jiexin Li1, Haisheng Zhang1, Hongsheng Wang1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
Abstract:
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and long non-coding RNA (lncRNA). m1A modification has impacts on the RNA processing, structure and functions of targets. Increasing studies reveal the critical roles of m1A modification and its regulators in tumorigenesis. Due to the positive relevance between m1A and cancer development, targeting m1A modification and m1A-related regulators has been of attention. In this review, we summarized the current understanding of m1A in RNAs, covering the modulation of m1A modification in cancer biology, as well as the possibility of targeting m1A modification as a potential target for cancer diagnosis and therapy.
Related Concept Videos
Epigenetic Regulation
X-chromosome...
RNA Editing
MicroRNAs
Spreading of Chromatin Modifications
Writers
The writer...
Abnormal Proliferation
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

