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Updated: Aug 19, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis, structure, and biological activity of 4-hetaryl-2-pyrrolidones containing a pyrazole ring
Natal'ya V Gorodnicheva1, Olga S Vasil'eva1, Evgeny S Ostroglyadov1
1Herzen State Pedagogical University of Russia, 48 Moyka River Embankment, Saint Petersburg, 191186 Russia.
Abstract:
Single diastereomers of 4-hetaryl-2-pyrrolidone-3(5)-carbo- and 2-[4-hetaryl-2-pyrrolidon-1-yl]acetohydrazides were used in reactions with 2,4-pentanedione, providing (3R*,4S*)-3-, (4R*,5R*)-5-(3,5-dimethyl-1H-pyrazole-1-carbonyl)- and 1-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-2-oxoethyl]-4-hetaryl-2-pyrrolidones. The structures of the synthesized compounds were confirmed by spectral methods and X-ray structural analysis. Some of the obtained compounds were shown to possess nootropic and anxiolytic activity.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s10593-022-03140-4.
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