Ultrahigh-Resolution Homo- and Heterodecoupled ¹H and TOCSY NMR Experiments

The original homonuclear decoupled (pure shift) experiments provide ultrahigh-resolution ¹H spectra of compounds containing NMR-active heteronuclei of low natural isotopic abundance (e.g., ¹³C or ¹⁵N). In contrast, molecules containing highly abundant heteronuclei (like ³¹P or ¹⁹F) give doublets or a multiple of doublets in their homonuclear decoupled spectra, depending on the number of heteronuclear coupling partners and the magnitude of the respective coupling constants. In these cases, the complex and frequently overlapping signals may hamper the unambiguous assignment of resonances. Here, we present new heteronuclear decoupled (HD) PSYCHE ¹H and TOCSY experiments, which result in simplified spectra with significantly increased resolution, allowing the reliable assessment of individual resonances. The utility of the experiments has been demonstrated on a challenging stereoisomeric mixture of a platinum-phosphine complex, where ultrahigh resolution of the obtained HD PSYCHE spectra made the structure elucidation of the chiral products feasible. HD PSYCHE methods can be potentially applied to other important ³¹P- or ¹⁹F-containing compounds in medicinal chemistry and metabolomics.