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Updated: Aug 19, 2025
07:30
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
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Therapeutic apheresis in sepsis
Gerd Klinkmann1, Jens Altrichter2, Daniel A Reuter1
1Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany.
Summary
Sepsis, a global health crisis, involves immune system dysregulation. Extracorporeal therapies show promise in rebalancing immune responses, with improving clinical evidence supporting their use in sepsis management.
Area of Science:
- Critical care medicine
- Immunology
- Nephrology
Background:
- Sepsis is a major cause of death globally, characterized by a dysregulated immune response leading to organ dysfunction.
- Understanding sepsis pathophysiology drives the development of therapies to modulate immune mediators.
- Extracorporeal techniques are being explored to manage the exaggerated inflammatory response in sepsis.
Approach:
- This work provides a comprehensive overview of extracorporeal therapies for sepsis.
- It details the technical aspects and clinical applications of these methods.
- The review focuses on the latest evidence and advancements in the field.
Key Points:
- Preclinical data suggest benefits of extracorporeal techniques in modulating sepsis-induced inflammation.
- Clinical trial quality and understanding of sepsis pathophysiology have improved.
- Extracorporeal therapies are increasingly recognized as part of sepsis treatment.
Conclusions:
- Extracorporeal therapies offer a promising avenue for managing sepsis by modulating immune responses.
- Continued research and high-quality clinical trials are essential to solidify their role.
- These techniques represent a significant advancement in the therapeutic arsenal against sepsis.
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