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Beyond cholesterol-pleiotropic effects of lipoprotein apheresis

Volker J J Schettler1, Elke Schettler2

  • 1Center of Nephrology Göttingen GbR, Göttingen, Germany.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|December 5, 2022
PubMed

Insights

Lipoprotein apheresis (LA) effectively treats severe hyperlipoproteinemia and impacts multiple factors contributing to atherosclerosis, including vascular inflammation and gene expression. This review explores LA

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Immunology

Background:

  • Cardiovascular disease, primarily atherosclerosis, is a major global mortality cause.
  • Atherosclerosis is a complex inflammatory disorder affecting multiple biological levels.
  • Severe hyperlipoproteinemia necessitates treatments like lipoprotein apheresis (LA).

Purpose of the Study:

  • To review the multifaceted effects of lipoprotein apheresis (LA) beyond lipid removal.
  • To discuss LA's impact on vascular inflammation, rheology, stem cell mobilization, and gene expression.
  • To highlight LA's role in addressing complex disorders like atherosclerosis.

Main Methods:

  • Literature review of lipoprotein apheresis (LA) studies.
  • Analysis of LA's impact on atherogenic factors.
  • Examination of LA's effects on extracellular microRNAs.

Main Results:

  • LA is a well-established treatment for severe hyperlipoproteinemia.
  • LA influences vascular inflammation, rheology, stem cell mobilization, and gene expression.
  • LA treatment reduces extracellular microRNAs involved in atherosclerotic processes.

Conclusions:

  • Lipoprotein apheresis (LA) is a complex therapeutic procedure.
  • LA offers a comprehensive approach to treating complex diseases like atherosclerosis.
  • LA demonstrates significant therapeutic potential by addressing multiple atherogenic pathways.

Keywords:
atherosclerosisexosomesinflammationlipoprotein apheresispleiotropic effects

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