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ROS-scavenging biomaterials for periodontitis
Enni Chen1, Tianyou Wang2, Yuan Tu1
1Department of Periodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China. shimengxiao817@163.com.
Journal of Materials Chemistry. B
|December 5, 2022
Summary
Reactive oxygen species (ROS) contribute to periodontitis. ROS-scavenging biomaterials show promise for treating this gum disease, with ongoing research into improved designs for clinical use.
Area of Science:
- Biomaterials Science
- Periodontology
- Oxidative Stress Research
Background:
- Periodontitis is a chronic inflammatory disease driven by excessive oxidative stress.
- The imbalance between reactive oxygen species (ROS) and antioxidant defenses is central to periodontitis pathogenesis.
- ROS-scavenging biomaterials are emerging as a therapeutic strategy for periodontitis.
Purpose of the Study:
- To review the intricate relationship between ROS and periodontitis.
- To explore the application of various ROS-scavenging biomaterials in periodontitis therapy.
- To summarize the current status and future directions for ROS-scavenging biomaterials in periodontal applications.
Main Methods:
- Literature review focusing on ROS, periodontitis, and biomaterial applications.
- Analysis of direct and indirect damage caused by ROS in periodontitis.
- Categorization of organic and inorganic ROS-scavenging biomaterials and their dosage forms.
Main Results:
- Detailed examination of ROS-induced damage in periodontitis.
- Overview of diverse ROS-scavenging biomaterials, including organic and inorganic types.
- Discussion of various delivery systems for periodontal therapy.
Conclusions:
- ROS-scavenging biomaterials offer a promising therapeutic avenue for periodontitis.
- Further development and improved design of these biomaterials are crucial for clinical translation.
- Enhanced ROS-scavenging biomaterials could significantly advance periodontal treatment options.
