Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorder of Water Balance01:29

Disorder of Water Balance

554
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
554
Entropy and Solvation02:05

Entropy and Solvation

7.1K
The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ...
7.1K
Aldehydes and Ketones with Water: Hydrate Formation01:20

Aldehydes and Ketones with Water: Hydrate Formation

3.4K
An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
3.4K
Membrane Fluidity01:26

Membrane Fluidity

11.5K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
11.5K
Aqueous Solutions and Heats of Hydration02:42

Aqueous Solutions and Heats of Hydration

14.8K
Water and other polar molecules are attracted to ions. The electrostatic attraction between an ion and a molecule with a dipole is called an ion-dipole attraction. These attractions play an important role in the dissolution of ionic compounds in water.
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
14.8K
Regulation of Water Intake01:25

Regulation of Water Intake

618
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
618

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyaluronic acid-phosphatidylcholine complexes as reductionist mimics of extracellular vesicle-mediated boundary lubrication in synovial joints.

Acta biomaterialia·2026
Same author

The Molecular Basis of Growth Control in Guanine Crystals.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Deep learning for enhancement of low-resolution and noisy scanning probe microscopy images.

Beilstein journal of nanotechnology·2025
Same author

Effects of Chemical Cross-Linking on the Structure of Proteins and Protein Assemblies.

Analytical chemistry·2025
Same author

Modulating the Curvature of Protein Self-Assembled Spiral Nanotubules.

ACS applied materials & interfaces·2025
Same author

E+: Software for Hierarchical Modeling of Electron Scattering from Complex Structures.

Journal of chemical information and modeling·2025
Same journal

Scalable batch-type synthesis of layered 2D-SnS<sub>2</sub> transistors integration enabled by BEOL-compatible low-thermal budget processes.

Nanoscale·2026
Same journal

Self-powered and gate-reconfigurable photodetection and logic operations in the Ta<sub>2</sub>PdS<sub>6</sub>/WSe<sub>2</sub> van der Waals heterostructure.

Nanoscale·2026
Same journal

Elucidating interfacial charge extraction from CdTe@ZnS quantum dots by pyridinium ionic liquids.

Nanoscale·2026
Same journal

Tailoring charged nanochannels in covalent organic framework membranes for efficient lithium recovery.

Nanoscale·2026
Same journal

Restoring the powerhouse: mitochondrial transplantation in regenerative medicine and cancer therapy.

Nanoscale·2026
Same journal

Enhanced circular dichroism of molecular J-aggregate-surface plasmon polariton hybrid modes.

Nanoscale·2026
See all related articles

Related Experiment Video

Updated: Aug 19, 2025

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
06:29

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Published on: May 2, 2020

3.9K

Dehydration does not affect lipid-based hydration lubrication.

Yihui Dong1, Nir Kampf1, Yaelle Schilt2

  • 1Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot, 76100, Israel. jacob.klein@weizmann.ac.il.

Nanoscale
|December 5, 2022
PubMed
Summary
This summary is machine-generated.

Phosphatidylcholine bilayers reduce friction via hydration lubrication. Unexpectedly, dehydration by dimethyl sulfoxide (DMSO) minimally impacted friction, revealing robust lipid lubrication mechanisms.

More Related Videos

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
08:23

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

Published on: July 10, 2016

18.5K
Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology
09:03

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology

Published on: June 21, 2013

22.3K

Related Experiment Videos

Last Updated: Aug 19, 2025

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
06:29

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Published on: May 2, 2020

3.9K
Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
08:23

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

Published on: July 10, 2016

18.5K
Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology
09:03

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology

Published on: June 21, 2013

22.3K

Area of Science:

  • Biophysics
  • Materials Science
  • Tribology

Background:

  • Phosphatidylcholine (PC) lipid bilayers provide essential lubrication in biological systems, notably in articular cartilage, through the hydration lubrication mechanism.
  • This mechanism relies on highly-hydrated phosphocholine headgroups and the intervening water layer for low friction.

Purpose of the Study:

  • To investigate the impact of dehydration on the lubrication properties of PC lipid bilayers using dimethyl sulfoxide (DMSO).
  • To elucidate the underlying mechanisms responsible for friction changes, or lack thereof, under dehydration conditions.

Main Methods:

  • Nanotribological measurements using atomic force microscopy.
  • Structural analysis via small- and wide-angle X-ray scattering.
  • Computational modeling using all-atom molecular dynamics simulations.

Main Results:

  • Dimethyl sulfoxide (DMSO) effectively removed hydration water from PC lipid headgroups, reducing the inter-bilayer water layer thickness.
  • Despite dehydration, sliding friction of the PC lipid bilayers remained largely unaffected.
  • Increased areal headgroup density and enhanced lipid bilayer rigidity compensated for water loss, reducing frictional dissipation.

Conclusions:

  • Lipid-based hydration lubrication is remarkably robust and resilient to dehydration, even in the presence of competing bio-osmolytes.
  • The findings highlight compensatory mechanisms involving headgroup density and bilayer mechanics that maintain low friction.