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Is thrombocytopenia and postnatal weight gain associated with treatment-requiring retinopathy of prematurity? A

Aikaterini K Seliniotaki1,2, Maria Lithoxopoulou3, Stella Moutzouri1

  • 12nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Acta Ophthalmologica
|December 5, 2022
PubMed

Insights

Platelet transfusions increase the risk of treatment-requiring retinopathy of prematurity (TR-ROP). Higher platelet counts and improved postnatal weight gain are associated with a decreased TR-ROP risk in infants.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Ophthalmology

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Understanding factors associated with treatment-requiring ROP (TR-ROP) is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between platelet parameters, postnatal weight gain, and the development of TR-ROP.
  • To identify potential biomarkers for predicting TR-ROP in high-risk infants.

Main Methods:

  • Retrospective matched case-control study design.
  • Inclusion of infants with TR-ROP and matched controls without ROP.
  • Collection of longitudinal data on platelet count (PLT), mean platelet volume (MPV), weight, and platelet transfusions.
  • Calculation of platelet mass index (PMI) and weight standard deviation score (WSDS).

Main Results:

  • Increased platelet count (PLT) during early postnatal life was associated with decreased odds of TR-ROP.
  • Infants receiving platelet transfusions had significantly higher odds of developing TR-ROP.
  • Higher platelet mass index (PMI) and improved weight gain (WSDS) were linked to reduced TR-ROP risk.
  • Mean platelet volume (MPV) and thrombopenic episodes showed no association with TR-ROP.

Conclusions:

  • Platelet transfusions may be associated with an increased risk of type I ROP.
  • Platelet parameters and postnatal weight gain are potential indicators for TR-ROP development.
  • Further prospective studies are needed to confirm these associations and guide clinical practice.
Abstract

Keywords:
ROPplateletsthrombocytopeniathrombopenictransfusionweight gain

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