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Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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Related Experiment Video

Updated: Aug 19, 2025

High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells
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High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells

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Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein.

Yuliu Chen1, Yan Wu2, Shaoying Chen1

  • 1NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical Universitygrid.284723.8, Guangzhou, China.

Journal of Virology
|December 5, 2022
PubMed
Summary

Sertraline (SRT) effectively inhibits SARS-CoV-2 entry by targeting the spike protein, showing promise as a COVID-19 therapeutic. This FDA-approved drug is effective against variants and safe for vulnerable populations.

Keywords:
SARS-CoV-2entry inhibitorinflammationsertralinespike

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Area of Science:

  • Virology
  • Drug Discovery
  • Immunology

Background:

  • The global prevalence of SARS-CoV-2 and its variants necessitates novel therapeutic strategies for COVID-19.
  • Existing treatments face challenges with emerging resistance and specific patient populations.

Purpose of the Study:

  • To screen FDA-approved amphiphilic drugs for antiviral activity against SARS-CoV-2.
  • To investigate the mechanism of action of identified drug candidates.
  • To evaluate efficacy in vitro and in vivo, including against SARS-CoV-2 variants.

Main Methods:

  • Screening of FDA-approved amphiphilic drugs.
  • In vitro assays using SARS-CoV-2 pseudovirus (PsV) and authentic virus.
  • In vivo studies in transduced mice.
  • Analysis of drug-target interactions (S protein, RBD, hACE2).

Main Results:

  • Sertraline (SRT) demonstrated potent in vitro antiviral activity against SARS-CoV-2.
  • SRT inhibits viral entry by blocking S protein-hACE2 interaction and S-mediated cell-cell fusion.
  • SRT is effective against SARS-CoV-2 variants, including Omicron, and shows synergistic effects with other antivirals.
  • In vivo studies showed SRT inhibited viral infection and reduced lung pathology in mice.

Conclusions:

  • Sertraline is a promising COVID-19 therapeutic candidate, acting as an effective entry inhibitor.
  • Its proven safety profile makes it suitable for vulnerable populations including the elderly, pregnant women, and those with cardiac complications.
  • SRT's potential for treating central nervous system infections warrants further investigation.