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Blood Pressure Measures and Incident Primary Open-Angle Glaucoma
Carmelo Macri1, Christopher X Wong2, Samuel J Tu2
1Discipline of Ophthalmology and Visual Sciences, The University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Investigative Ophthalmology & Visual Science
|December 5, 2022
Summary
Higher systolic blood pressure (SBP) and pulse pressure (PP) increase the risk of developing primary open-angle glaucoma (POAG). This large study highlights blood pressure as a potential factor in POAG development.
Area of Science:
- Ophthalmology
- Cardiovascular Health
- Epidemiology
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
- Systemic blood pressure is a modifiable risk factor with potential implications for ocular health.
Purpose of the Study:
- To investigate the association between systemic blood pressure parameters and the incidence of primary open-angle glaucoma (POAG).
Main Methods:
- A prospective cohort study utilizing the UK Biobank database, including 484,268 participants.
- Incident POAG events were tracked through various health records over a median follow-up of 12.08 years.
- Systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP) were analyzed as time-varying covariables.
Main Results:
- Higher SBP and PP were significantly associated with an increased risk of incident POAG.
- Elevated SBP (130-150 mmHg) and PP (>70 mmHg) showed a higher hazard ratio for developing POAG.
- No significant associations were found between DBP or MAP and incident POAG.
Conclusions:
- Elevated systolic blood pressure and pulse pressure are linked to a greater risk of developing primary open-angle glaucoma.
- Further research is needed to fully understand and potentially leverage these blood pressure-glaucoma associations.
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