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Related Concept Videos

Genomics02:02

Genomics

36.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Human Genetics01:28

Human Genetics

664
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
664
Polygenic Traits01:18

Polygenic Traits

66.3K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.3K
Pleiotropy01:33

Pleiotropy

40.8K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.8K
Incomplete Dominance01:43

Incomplete Dominance

25.0K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
25.0K

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Related Experiment Video

Updated: Aug 19, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

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Genomics and multimorbidity.

Jane A H Masoli1,2, Luke C Pilling1, Timothy M Frayling1

  • 1Department of Clinical and Biomedical Science, University of Exeter, Exeter, Devon EX12LU, UK.

Age and Ageing
|December 5, 2022
PubMed
Summary
This summary is machine-generated.

Genomic medicine offers new insights into multimorbidity, the simultaneous occurrence of multiple chronic diseases. Understanding genetic factors can improve disease risk prediction, diagnosis, and treatment strategies for complex health conditions.

Keywords:
geneticgenomicolder peoplepersonalisedprecision

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Area of Science:

  • Genomics and Precision Medicine
  • Public Health Research

Background:

  • Multimorbidity is a growing global health challenge, projected to affect a significant portion of the population.
  • Genomic medicine has advanced rapidly, moving from basic research to clinical applications for rare diseases.
  • Genetic factors influence disease development and medication response, presenting opportunities for personalized healthcare.

Purpose of the Study:

  • To explore the role of genomics in understanding the mechanisms of multimorbidity.
  • To discuss the potential of genomic approaches in managing multiple long-term conditions.
  • To highlight the utility of genomics for precision medicine in the context of multimorbidity.

Main Methods:

  • This commentary synthesizes current knowledge on genomics and its application to multimorbidity.
  • It reviews the advantages of genetic studies over traditional epidemiological methods due to reduced bias and confounding.
  • The discussion includes the concept of pharmacogenetics in relation to medication efficacy and adverse effects.

Main Results:

  • Genomic studies can uncover novel disease mechanisms underlying multimorbidity.
  • Genetic variations impact drug efficacy and side effect risks, forming the basis of pharmacogenetics.
  • Genomic approaches promise to enhance the understanding and management of complex health conditions.

Conclusions:

  • Genomics holds significant potential for advancing the understanding of multimorbidity.
  • Precision approaches guided by genomic data can optimize risk assessment, diagnosis, and treatment for patients with multiple conditions.
  • Genomic medicine is poised to play a crucial role in addressing the global priority of multimorbidity.