[Thalidomide embryopathy 60 years]

This review describes the recognition and effects of thalidomide as a potent teratogenic agent sixty years ago. A systematic analysis revealed a broad spectrum of multiple congenital birth defects involving many organ systems. More than 5000 affected individuals have been observed in Germany, more than 10 000 globally. Today about 2400 adults live with chronic late manifestations. In contrast to Europe and Canada, the thalidomide embryopathy did not occur in the United States of America: A physician responsible at the FDA had noted inconsistencies in the description of thalidomide. The GDR, too, did not market the drug.