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Updated: Aug 11, 2026

Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
Published on: April 15, 2014
Monkeypox encephalitis with transverse myelitis in a female patient
Joby Cole1, Saher Choudry2, Saminderjit Kular3
1Department of Infectious Diseases and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; Department of Infection, Immunity, and Cardiovascular Diseases, University of Sheffield, Sheffield, UK.
The 2022 monkeypox outbreak caused rare neurological complications like encephalitis and transverse myelitis. Prompt treatment with antivirals and supportive care led to significant recovery in a 35-year-old woman.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- The 2022 global monkeypox outbreak, declared a public health emergency, presents diverse clinical manifestations.
- Neurological complications of monkeypox are uncommon but can be severe, with limited established treatments.
Observation:
- A previously healthy 35-year-old woman developed encephalitis and transverse myelitis during the monkeypox outbreak.
- Her neurological symptoms were severe, impacting her quality of life.
Findings:
- The patient received a combination of tecovirimat, cidofovir, steroids, and plasma exchange.
- She experienced an almost complete recovery from her neurological deficits following this multi-modal treatment approach.
Implications:
- This case highlights the potential for severe neurological involvement in monkeypox virus infections.
- The successful treatment suggests that aggressive management with antivirals and supportive therapies may improve outcomes for neurological complications.
- Further research into monkeypox-associated neurological disorders and their therapeutic strategies is warranted.
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