Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

2.6K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
2.6K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
Arteries and Arterioles01:16

Arteries and Arterioles

4.5K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
4.5K
Aging01:26

Aging

145
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
145
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

35
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
35
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

3.2K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors analysis for extubation failure following mandibular distraction osteogenesis in infants with Pierre Robin sequence: a retrospective cohort study.

Frontiers in pediatrics·2026
Same author

Identification of an Angiotensin-(1-7)-Producing fusion protein in the brain of transgenic rats Reveals a hypotensive effect mediated through modulation of the GABA-nNOS-NO pathway and highlighting Astrocyte-Neuron crosstalk.

Neuroscience·2026
Same author

Chronic kidney disease and mortality in fragility fracture patients: revisiting GFR thresholds.

European geriatric medicine·2025
Same author

Chronic Treatment with Angiotensin-(1-7) Improves Metabolism by Modulating Adipose Tissue and Oxidative Stress in Mice.

Anti-inflammatory & anti-allergy agents in medicinal chemistry·2025
Same author

Effective Therapeutic Strategies to Prevent Frailty and Falls in Community-Dwelling Older Adults.

Aging and disease·2025
Same author

Single-Cell RNA Sequencing Delineates Renal Anti-Fibrotic Mechanisms Mediated by TRPC6 Inhibition.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Related Experiment Video

Updated: Aug 18, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.9K

Arterial myogenic response and aging.

Yingqiu Cui1, Maik Gollasch2, Mario Kassmann2

  • 1Charité - Universitätsmedizin Berlin, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC), Lindenberger Weg 80, 13125 Berlin, Germany.

Ageing Research Reviews
|December 5, 2022
PubMed
Summary

The arterial myogenic response, vital for blood flow regulation, involves mechano-activated angiotensin II type 1 receptors (AT1R). Aging impacts this response, affecting mechanisms and healthy aging.

Keywords:
AgingIon channelsMyogenic responseVascular smooth muscle

More Related Videos

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography
10:48

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography

Published on: July 6, 2015

17.1K
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.6K

Related Experiment Videos

Last Updated: Aug 18, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.9K
Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography
10:48

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography

Published on: July 6, 2015

17.1K
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.6K

Area of Science:

  • Physiology
  • Cardiovascular Biology
  • Mechanobiology

Background:

  • The arterial myogenic response is a key physiological mechanism in resistance arteries.
  • It maintains constant blood flow by adjusting vascular tone against pressure changes.
  • Molecular underpinnings, particularly mechanosensors, remain incompletely understood.

Purpose of the Study:

  • To review recent advancements in understanding the role of angiotensin II type 1 receptors (AT1R) and other mechanosensors in arterial myogenic response.
  • To explore the impact of aging on myogenic response and its underlying molecular mechanisms.
  • To discuss the implications of these findings for healthy aging.

Main Methods:

  • Literature review of recent studies on arterial myogenic response.
  • Focus on mechano-activated receptors, particularly AT1R.
  • Analysis of age-related changes in vascular function.

Main Results:

  • Mechano-activated AT1R play a critical role in the arterial myogenic response.
  • Aging significantly alters the development and function of the myogenic response.
  • Specific molecular mechanisms contributing to age-related alterations are being elucidated.

Conclusions:

  • AT1R and other mechanosensors are crucial for regulating arterial myogenic tone.
  • Age-related changes in these mechanisms can impact cardiovascular health.
  • Further research is needed to fully understand and potentially mitigate age-associated vascular dysfunction.