Related Experiment Video
Updated: Aug 18, 2025

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
Lynne Krohn1,2, Karl Heilbron3, Cornelis Blauwendraat4
1Department of Human Genetics, McGill University, Montréal, QC, Canada.
Abstract:
Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more severe subtype. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we perform a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB2. Expression analyses highlight SNCA-AS1 and potentially SCARB2 differential expression in different brain regions in RBD, with SNCA-AS1 further supported by colocalization analyses. Polygenic risk score, pathway analysis, and genetic correlations provide further insights into RBD genetics, highlighting RBD as a unique alpha-synucleinopathy subpopulation that will allow future early intervention.
More Related Videos
08:58Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
Published on: June 19, 2019
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Related Concept Videos
REM Sleep Behavior Disorder
RBD is significantly associated with...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Narcolepsy
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge: