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The Incidence and Outcomes for Children with Cleft Palate and/or Lip and CHARGE Syndrome

Mohammed Farid1, Louise Cafferky1, Jeremy Kirk2

  • 1West Midlands Cleft Centre, Birmingham Children's Hospital, Birmingham, UK.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|December 6, 2022
PubMed

Insights

Children with cleft lip/palate and CHARGE syndrome often have severe medical issues, leading to delayed surgeries. Outcomes for feeding and communication were better in older children.

Area of Science:

  • Pediatric surgery
  • Genetics
  • Craniofacial anomalies

Background:

  • Literature on children with cleft palate and/or lip (CP +/-L) and CHARGE syndrome (CS) is limited.
  • This population presents unique challenges in surgical management and developmental outcomes.

Purpose of the Study:

  • To investigate cleft characteristics, surgical timing, and feeding/communication outcomes in children with CP +/-L and CS.
  • To identify factors influencing outcomes in this complex patient group.

Main Methods:

  • Retrospective cross-sectional review of patients diagnosed with CP +/-L and CS between 1989-2019.
  • Data collected included cleft type, timing of surgical repair, feeding methods, and communication modalities.

Main Results:

  • Twenty-two children with CP +/-L and CS were identified, with bilateral cleft lip and palate (BCLP) being the most common type (50%).
  • Cleft repair was significantly delayed compared to non-syndromic controls, with median ages of 9 months for lip repair and 21 months for palate repair.
  • Only 27% achieved full oral feeding and verbal communication; outcomes improved in children over ten years old.

Conclusions:

  • Children with CP +/-L and CS exhibit severe cleft types and significant medical comorbidities, contributing to delayed surgical interventions.
  • Optimizing feeding and communication requires long-term, multidisciplinary management, with better outcomes observed in older children.
Abstract

Keywords:
CHARGE syndromecleft lip and palatecommunicationfeeding

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