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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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[Clinical and pathologic features of nephropathy with C1q deposits]

N V Chebotareva1, A A Vinogradov1, A N Grishina1

  • 1Sechenov First Moscow State Medical University (Sechenov University).

Terapevticheskii Arkhiv
|December 6, 2022
PubMed

Insights

C1q deposits in the kidneys were found in 4.05% of chronic glomerulonephritis patients. Membranous nephropathy was the most common form, often presenting with nephrotic syndrome and sometimes renal dysfunction.

Area of Science:

  • Nephrology
  • Immunopathology
  • Glomerular Diseases

Context:

  • Chronic glomerulonephritis (CGN) encompasses various kidney diseases.
  • C1q is a component of the complement system, implicated in immune complex-mediated kidney damage.
  • Understanding C1q deposition patterns aids in diagnosing and managing CGN.

Purpose:

  • To investigate the prevalence and characteristics of nephropathy associated with C1q deposits in adult CGN patients.
  • To identify the specific morphological types and clinical presentations of CGN with C1q deposition.
  • To analyze the association between C1q deposits and disease progression in CGN.

Summary:

  • A study analyzed 296 kidney biopsy specimens from CGN patients (2014-2018), excluding lupus nephritis and primary membranoproliferative glomerulonephritis.
  • C1q deposits were identified in 4.05% (12/296) of CGN cases using immunofluorescence.
  • Morphologically, membranous nephropathy (8 cases) was most common, followed by mesangioproliferative glomerulonephritis (2 cases) and nephrosclerosis (2 cases).
  • Clinically, 5 patients presented with nephrotic syndrome initially, while others developed it after proteinuria. Renal dysfunction was noted in 7 patients, with 2 progressing to renal failure within a year.

Impact:

  • This study highlights C1q deposition as a relevant finding in a subset of CGN patients.
  • It underscores the association of C1q deposits with membranous nephropathy and nephrotic syndrome.
  • The findings contribute to a better understanding of CGN pathogenesis and clinical outcomes, potentially guiding diagnostic and therapeutic strategies.
Abstract

Keywords:
chronic glomerulonephritiskidney biopsy

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