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Updated: Aug 18, 2025

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Published on: March 8, 2024

[A new xanthone from Hypericum lagarocladum].

Jing-Tong Deng¹, Tong-Xi Zhou², Ying-Chun Yang²

¹School of Pharmaceutical Sciences, South-Central Minzu University Wuhan 430074, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|December 6, 2022

Summary

Researchers isolated ten xanthones from Hypericum lagarocladum, including a new compound, lagarxanthone A. None of the isolated compounds significantly affected glucose uptake in L6 cells.

Keywords:

Hypericum lagarocladum chemical component glucose uptake xanthone

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Area of Science:

Phytochemistry
Natural Product Chemistry
Pharmacology

Context:

Hypericum species are known for their diverse chemical constituents.
Investigating the chemical profile of Hypericum lagarocladum can reveal novel compounds.
Understanding the biological activities of isolated compounds is crucial for potential therapeutic applications.

Purpose:

To isolate and characterize chemical constituents from Hypericum lagarocladum.
To identify novel compounds and report new occurrences of known compounds in this plant.
To evaluate the effect of isolated compounds on glucose uptake in L6 cells.

Summary:

Ten xanthone derivatives were isolated from the ethyl acetate fraction of Hypericum lagarocladum using various chromatographic techniques.
The structures were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.
Lagarxanthone A (1) is a new compound, while compounds 2-10 were reported for the first time from this plant.

Impact:

This study expands the known chemical diversity of the Hypericum genus.
The identification of novel xanthones provides a basis for further pharmacological investigations.
The lack of significant effect on glucose uptake suggests these compounds may not be suitable for diabetes treatment via this mechanism.