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MARKER DIAGNOSTIC HEART FAILURE PROGRESSION IN THE POST-INFARCTION PERIOD

Khrystyna V Levandovska1, Ihor P Vakaliuk1, Tetiana V Naluzhna1

  • 1IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|December 6, 2022
PubMed

Insights

Biomarkers like NT-proBNP and copeptin can predict decompensated heart failure (HF) after acute myocardial infarction (AMI). Elevated levels of these markers, along with ST2, are crucial for assessing post-infarction outcomes.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Heart Failure Management

Background:

  • Acute myocardial infarction (AMI) can lead to decompensated heart failure (HF).
  • Predictive biomarkers are essential for managing post-MI complications.
  • Myocardial remodeling indicators play a role in HF progression.

Purpose of the Study:

  • To investigate the relationship between copeptin, NT-proBNP, ST2 levels, and myocardial remodeling.
  • To assess the dynamic changes of these biomarkers for predicting decompensated HF post-AMI.
  • To evaluate the prognostic significance of these markers in the post-infarction period.

Main Methods:

  • Study included 160 patients with MI (120 with decompensated HF, 40 without), and 20 healthy controls.
  • Measured serum levels of copeptin, NT-proBNP, and ST2.
  • Assessed patient response to dosed physical exertion.

Main Results:

  • Patients with decompensated HF showed significantly higher NT-proBNP levels (950.38±3.15 pg/ml) compared to those without (580.15±3.03 pg/ml) and healthy individuals (111.20±3.47 pg/ml).
  • Mean copeptin concentration was higher in patients with decompensated HF (18.11±0.12 pg/ml) versus those without (12.03±0.14 pg/ml).
  • Elevated NT-proBNP, copeptin, and ST2 levels were observed in patients with decompensated HF.

Conclusions:

  • NT-proBNP, copeptin, and ST2 levels are significant indicators for assessing the post-infarction period complicated by decompensated HF.
  • Patient response to physical exertion, alongside biomarker levels, is crucial for clinical and prognostic evaluation.
  • These biomarkers aid in predicting and managing decompensated heart failure following acute myocardial infarction.
Abstract

Keywords:
NT-proBNPcopeptindecompensated heart failurepostinfarction cardiosclerosissST2

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