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Updated: Aug 18, 2025

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Aligning Semantic Interoperability Frameworks with the FOXS Stack for FAIR Health Data.

John Meredith1, Nik Whitehead2, Michael Dacey2

  • 1Wales Institute of Digital Information, Digital Health and Care Wales, Cardiff, United Kingdom.

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|December 6, 2022
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Summary

The FOXS platform aligns with the European Open Science Cloud Interoperability Framework, enhancing semantic interoperability for digital health records. This supports FAIR data principles for robust health research.

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Area of Science:

  • Health Informatics
  • Data Interoperability
  • Semantic Web Technologies

Background:

  • FAIR Guiding Principles (Findable, Accessible, Interoperable, Reusable) are crucial for digital health records, enabling data discovery, accessibility, system interoperability, and reuse.
  • The combination of HL7 FHIR, openEHR, IHE XDS, and SNOMED CT (FOXS) forms a specification for an open digital health platform designed for modern healthcare applications.

Purpose of the Study:

  • To map FOXS components to the European Open Science Cloud Interoperability Framework (EOSC-IF) reference architecture, focusing on semantic interoperability.
  • To assess FOXS alignment with FAIR principles and identify data models supporting longitudinal care records for scientific research.

Main Methods:

  • Analyzed the EOSC-IF Semantic View, which represents semantic interoperability ensuring meaning preservation across systems and users.
  • Cross-referenced EOSC-IF Semantic View components with FOXS architectural elements, mapping concepts and objects like catalogues and semantic artifacts.

Main Results:

  • A majority of conceptual Semantic View components were identified within the FOXS architecture.
  • FOXS Semantic Business Objects integrate elements such as openEHR archetypes/templates, FHIR resources/profiles, SNOMED CT concepts, and XDS document identifiers.
  • Semantic Functional Content, including metadata catalogues, is supported by openEHR and FHIR tools within the FOXS platform.

Conclusions:

  • The FOXS platform demonstrates broad conformance to EOSC-IF concepts and framework components, despite some vague elements like FAIR Digital Objects.
  • This study validates a health-domain-specific approach to semantic interoperability, facilitating FAIR data for health research through a standardized framework.