Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

24.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
24.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Stem Cell Culture01:17

Stem Cell Culture

5.3K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.3K
Unrenewable Cells00:50

Unrenewable Cells

2.3K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Optogenetic reactivation of dormant cone photoreceptors].

Die Ophthalmologie·2026
Same author

Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling.

ACS nano·2025
Same author

Author Correction: Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.

Nature communications·2025
Same author

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.

Nature communications·2024
Same author

A subgroup of light-driven sodium pumps with an additional Schiff base counterion.

Nature communications·2024
Same author

Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia.

Nature protocols·2023
Same journal

Readability of patient educational materials on ultrasound: a cross-sectional study.

Journal of perinatal medicine·2026
Same journal

Correlations between fetal left ventricular Tei index and different hemodynamic parameters during middle and late pregnancy at high altitudes.

Journal of perinatal medicine·2026
Same journal

The role of Coroners in perinatal death investigation in high-income countries: a scoping review.

Journal of perinatal medicine·2026
Same journal

The cytokine Prokineticin-1 in preterm labor with and without intra-amniotic inflammation.

Journal of perinatal medicine·2026
Same journal

Birth weight percentiles in infants with neonatal-onset prolonged neonatal hypoglycemia and persistent congenital hyperinsulinism.

Journal of perinatal medicine·2026
Same journal

Limits of viability: are we heading in right direction?

Journal of perinatal medicine·2026
See all related articles

Related Experiment Video

Updated: Aug 18, 2025

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases
07:46

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Published on: October 6, 2023

1.0K

Stem cells for treating retinal degeneration.

Volker Busskamp1

  • 1Degenerative Retinal Diseases, University Hospital Bonn, Venusberg-Campus 1 Gebäude 5, 53127 Bonn, Germany.

Journal of Perinatal Medicine
|December 7, 2022
PubMed
Summary
This summary is machine-generated.

Human stem cells offer new hope for vision restoration by replacing damaged retinal cells. Cell replacement therapy shows promise for treating blindness caused by retinal degenerative diseases.

Keywords:
retinal pigment epithelium (RPE)stem cells

More Related Videos

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

3.6K
Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.0K

Related Experiment Videos

Last Updated: Aug 18, 2025

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases
07:46

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Published on: October 6, 2023

1.0K
Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

3.6K
Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.0K

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Mammalian retinas have limited regenerative capacity, making vision loss permanent after cell damage.
  • Genetic and traumatic insults to retinal neurons and retinal pigment epithelium (RPE) can cause blindness.
  • Rodent models are useful for monogenetic retinal diseases but poorly model complex conditions like age-related macular degeneration (AMD).

Purpose of the Study:

  • To explore the potential of human stem cells for vision restoration.
  • To highlight the importance of cell replacement therapy for retinal degenerative diseases.
  • To discuss the application and limitations of stem cell-based therapies in clinical settings.

Main Methods:

  • Utilizing human stem cells for therapeutic development.
  • Employing cell replacement strategies, including RPE and photoreceptor transplantation.
  • Analyzing successes and challenges of current cell-based vision restoration approaches.

Main Results:

  • Human stem cells are valuable tools for developing therapies for complex retinal diseases.
  • Cell replacement therapy, particularly RPE cell substitution, is a key strategy for vision restoration.
  • Different retinal disorders may necessitate transplantation of specific cell types or combinations.

Conclusions:

  • Stem cell-based therapies, especially cell replacement, hold significant promise for treating retinal degenerative diseases.
  • The article reviews the principles, successes, and limitations of cell replacement therapies for vision restoration.
  • Further research is needed to overcome shortcomings for successful clinical application.