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Characteristics of the 6th Japanese wave of COVID-19 in hemodialysis patients

Munenori Haruta1, Shigeru Otsubo1,2, Yuriko Otsubo2

  • 1Department of Clinical Engineering, Faculty of Human Care at Makuhari, Tohto University, 1-1 Hibino, Mihama-Ward, Chiba-City, Chiba-Prefecture 261-0021 Japan.

Renal Replacement Therapy
|December 7, 2022
PubMed

Insights

COVID-19 outcomes improved for hemodialysis patients in Japan during the 6th wave. Increased vaccination rates and advanced treatments, including neutralizing antibodies and molnupiravir, led to better prognoses and fewer critical cases.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 poses significant risks to hemodialysis patients.
  • The 6th wave in Japan was primarily driven by the Omicron variant.
  • Understanding clinical characteristics during different infection waves is crucial for patient management.

Purpose of the Study:

  • To compare the clinical characteristics and outcomes of hemodialysis patients with COVID-19 between the 1st-5th waves and the 6th wave in Japan.
  • To assess the impact of vaccination and new treatments on patient prognosis.

Main Methods:

  • Retrospective cohort study comparing two groups of hemodialysis patients.
  • Group 1: Patients admitted from January 2022 onwards (6th wave, n=53).
  • Group 2: Patients admitted during the 1st-5th waves (n=47).

Main Results:

  • The 6th wave group had significantly higher vaccination rates (96.2% vs 10.6%).
  • Use of neutralizing antibodies and molnupiravir was more frequent in the 6th wave group.
  • Critical COVID-19 disease was absent in the 6th wave group, compared to 21.3% in the earlier waves.

Conclusions:

  • Hemodialysis patients in Japan experienced improved outcomes during the 6th COVID-19 wave.
  • Increased vaccination coverage and advancements in antiviral treatments likely contributed to the better prognosis.
Abstract

Keywords:
6th Japanese waveCOVID-19HemodialysisOmicron variantSARS-CoV-2

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