Related Experiment Video

Updated: Aug 18, 2025

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
05:52

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

1.4K

The course of COVID-19 in patients with hematological malignancies and risk factors affecting mortality: A

Esma Eryilmaz-Eren1, Zeynep Ture2, Ayşin Kilinç-Toker1

  • 1Kayseri City Education and Research Hospital, Kayseri, Turkey.

Hematology, Transfusion and Cell Therapy
|December 7, 2022
PubMed

Insights

Older age and secondary infections increase COVID-19 mortality risk in hematological malignancy patients. Hematological malignancy remission status is protective. These factors predict survival in this vulnerable population.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • Hematological malignancy (HM) patients face increased risks from COVID-19.
  • Understanding mortality risk factors is crucial for managing these complex cases.

Purpose of the Study:

  • To identify clinical outcomes and mortality risk factors in COVID-19 patients with hematological malignancy.
  • To analyze prognostic factors influencing survival in this specific patient cohort.

Main Methods:

  • Retrospective study of 49 patients diagnosed with HM and hospitalized for COVID-19.
  • Comparison of demographic, clinical characteristics, prognosis, and treatment between survivors and non-survivors.
  • Multivariate regression analysis to determine independent risk and protective factors.

Main Results:

  • Overall mortality rate was 34.6% within 28 days.
  • Non-survivors had higher rates of older age, diabetes, COPD, and secondary infections.
  • Hematological malignancy remission status was significantly higher in survivors.
  • Multivariate analysis identified older age and secondary infection as mortality risk factors, and HM remission as a protective factor.

Conclusions:

  • Older age, secondary infections, and hematological malignancy remission status are key prognostic factors for COVID-19 mortality in HM patients.
  • Early identification and management of these factors are essential for improving patient outcomes.
Abstract

Keywords:
COVID-19Hematological malignancyOlder ageRemission

More Related Videos

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

3.7K
Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models08:14

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Published on: October 3, 2019

12.3K

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
1.5K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
388
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.5K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
413
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.4K