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Clinical Characteristics and Prognosis Analysis of Acinetobacter baumannii Bloodstream Infection Based on Propensity
Jinghui Wang1, Jun Zhang2, Zhuang-Hao Wu1
1Department of Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Purpose:
In view of the fact that Acinetobacter baumannii bloodstream infection(BSI) is a great threat to human survival, early identification of the risk factors affecting prognosis will be of great benefit to the clinic.
Patients And Methods:
A propensity score matching method was used to collect patients identified with Acinetobacter baumannii BSI from 2016 to 2020 from a reputable hospital in China.
Results:
A total of 398 patients were considered. According to the 28-day prognosis, they were divided into the survival group 150 (37.7%) and the death group 248 (62.3%), and the prognosis was analyzed. Subsequently, Propensity score matching was adjusted for variables with p-values
Conclusion:
The existence of drug resistance with Acinetobacter baumannii only leads to Inappropriate empirical antibiotic therapy, ultimately, Inappropriate empirical antibiotic therapy was the direct predictor of mortality.
Insights
Early identification of risk factors for Acinetobacter baumannii bloodstream infection (BSI) is crucial. Higher SOFA scores, septic shock, and mechanical ventilation predict poor prognosis, while inappropriate antibiotic therapy is a direct mortality predictor.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Antimicrobial Resistance
Background:
- Acinetobacter baumannii bloodstream infection (BSI) poses a significant threat to patient survival.
- Identifying prognostic risk factors for A. baumannii BSI is critical for clinical management.
- Drug resistance in A. baumannii complicates treatment and impacts outcomes.
Purpose of the Study:
- To identify early risk factors influencing the prognosis of Acinetobacter baumannii bloodstream infections.
- To analyze the predictors of mortality in patients with A. baumannii BSI.
Main Methods:
- A retrospective study involving 398 patients with A. baumannii BSI from 2016-2020.
- Propensity score matching was employed to adjust for baseline differences.
- Multivariate logistic regression analysis was performed on matched patient data.
Main Results:
- A total of 398 patients were analyzed, with 248 (62.3%) experiencing mortality within 28 days.
- Matched analysis of 63 patients revealed that higher SOFA scores, septic shock, and mechanical ventilation were associated with poor prognosis.
- Inappropriate empirical antibiotic therapy was identified as a direct predictor of mortality.
Conclusions:
- Higher SOFA scores, septic shock, and mechanical ventilation are significant risk factors for mortality in A. baumannii BSI.
- Inappropriate empirical antibiotic therapy, often linked to drug resistance, directly predicts mortality in these infections.
- These findings underscore the importance of timely and appropriate antibiotic selection for Acinetobacter baumannii BSI.
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