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Applications and prospects of targeted therapy for neuroblastoma
1Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.
Background:
Neuroblastoma is an extremely malignant tumor in children. For advanced or recurrent cases, existing treatment modalities are limited and efficacy remains disappointing. With the improvement in understanding of molecular biology of neuroblastoma and the development of clinical trials of targeted drug therapy, a variety of targeted therapies for neuroblastoma have appeared.
Data Sources:
All the recent literatures on targeted therapies of neuroblastoma on PubMed were searched and reviewed.
Results:
This article reviewed targeted therapies of neuroblastoma going through clinical trials and obtained preliminary results. The features, advantages and disadvantages of targeted radiation therapy,immunotherapy, gene and pathway molecular inhibitor and angiogenesis inhibitor were discussed.
Conclusion:
This study provides references for better understanding the current progress of targeted therapies for neuroblastoma.
Insights
New targeted therapies are emerging for neuroblastoma, a severe childhood cancer. This review discusses promising treatments like immunotherapy and molecular inhibitors currently in clinical trials.
Area of Science:
- Pediatric Oncology
- Cancer Molecular Biology
- Pharmacological Research
Background:
- Neuroblastoma is a highly malignant pediatric cancer with limited treatment options for advanced or recurrent cases.
- Understanding the molecular biology of neuroblastoma has led to the development of targeted therapies.
- Current treatments for advanced or recurrent neuroblastoma show disappointing efficacy.
Purpose of the Study:
- To review recent advancements in targeted therapies for neuroblastoma.
- To discuss the features, advantages, and disadvantages of various targeted treatment modalities.
- To provide insights into the progress of neuroblastoma targeted therapies in clinical trials.
Main Methods:
- A comprehensive literature search of PubMed was conducted for recent studies on neuroblastoma targeted therapies.
- Reviewed articles focused on targeted therapies currently undergoing clinical trials.
- Analyzed data on targeted radiation therapy, immunotherapy, molecular inhibitors, and angiogenesis inhibitors.
Main Results:
- Several targeted therapies for neuroblastoma are under investigation in clinical trials.
- Preliminary results indicate potential efficacy for various targeted approaches.
- The review discusses the characteristics, benefits, and drawbacks of different targeted treatment strategies.
Conclusions:
- Targeted therapies represent a promising frontier in neuroblastoma treatment.
- This review offers valuable references for understanding the current landscape of neuroblastoma targeted therapies.
- Further research and clinical trials are essential to optimize these novel treatment strategies.
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