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Targeting autophagy in neuroblastoma
1Department of Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University, Shanghai, China.
World Journal of Pediatric Surgery
|December 7, 2022
Summary
Neuroblastoma (NB) is a common childhood cancer. Inhibiting autophagy, a cellular process, may improve treatment outcomes for high-risk NB patients.
Area of Science:
- Oncology
- Cellular Biology
Background:
- Neuroblastoma (NB) is the most frequent pediatric solid tumor with significant mortality.
- Macroautophagy, a cellular homeostasis mechanism, plays a role in cancer development and chemoresistance.
Purpose of the Study:
- To review the literature on the role of autophagy in neuroblastoma.
- To determine if autophagy inhibition could be a therapeutic strategy for NB.
Main Methods:
- Literature search of PubMed using terms 'autophagy' and 'neuroblastoma'.
- Review of recent publications.
Main Results:
- Autophagy is implicated in apoptosis, histone modifications, angiogenesis, and metabolism in NB.
- Evidence suggests NB is an autophagy-dependent tumor.
Conclusions:
- Autophagy promotes oncogenesis in NB.
- Inhibiting autophagy in high-risk NB could enhance treatment efficacy.
Keywords:
pediatrics
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