[Transgenesis in Worms: Candidates for an Ideal Model]

Area of Science:

• Zoology
• Genetics
• Developmental Biology

Context:

• Transgenesis is vital for understanding complex biological processes in animals.
• Developing transgenic animal lines requires efficient and cost-effective model organisms.
• A suitable model organism must possess specific traits amenable to genetic manipulation.

Purpose:

• To review existing model organisms across various taxa with established efficient transgenesis protocols.
• To identify and evaluate promising model organisms for future research.
• To highlight the potential of Macrostomum lignano as a model for specific biological studies.

Summary:

• This review surveys model organisms suitable for transgenesis across different animal groups.
• It details the requirements for efficient and affordable transgenesis.
• Macrostomum lignano is presented as a particularly promising model for studying aging, regeneration, and carcinogenesis.

Impact:

• Facilitates the selection of appropriate model organisms for diverse research questions.
• Supports the advancement of genetic research and the creation of novel transgenic models.
• Establishes Macrostomum lignano as a key organism for investigating aging, regeneration, and cancer development.