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Updated: Aug 18, 2025

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

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[Mechanism of Leakage in Phosphatidylserine-Containing Membranes by Melittin]

R Wang1,2, M-Y Shi1, B-B Ma1,2

  • 1Xinjiang Laboratory of Phase Transitions and Microstructures of Condensed Matter Physics, College of Physical Science and Technology, Yili Normal University, Yining, 835000 China.

Molekuliarnaia Biologiia
|December 7, 2022
PubMed

Insights

Melittin interacts with phosphatidylserine (PS) membranes by forming pores, with unsaturated PS membranes showing distinct behavior from saturated ones. This finding aids anticancer drug development.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Biophysics
Keywords:
concentration dependencegiant unilamellar vesiclemelittinpeptide-induced permeationphosphatidylserine lipid bilayer

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