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Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

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Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain.

Tatiana N Tikhonova^1,2, Dana Cohen-Gerassi³, Zohar A Arnon³

¹Department of Physics, M.V. Lomonosov Moscow State University, Leninskie gory 1/2, Moscow119991, Russia.

ACS Applied Materials & Interfaces

|December 8, 2022

Summary

New peptide-based hydrogels create sensitive defrost sensors for the pharmaceutical cold chain. These room-temperature-stable sensors irreversibly indicate thawing, ensuring medication and biomaterial integrity during transport and storage.

Keywords:

defrost sensor fibrillation hydrogel peptide self-assembly pharma cold chain

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Area of Science:

Biomaterials Science
Chemical Engineering
Pharmaceutical Technology

Background:

The pharmaceutical cold chain relies on precise temperature control to maintain the efficacy of medications and biomaterials.
Current monitoring methods may lack sensitivity, irreversibility, or long-term stability at ambient temperatures.
A need exists for advanced sensing technologies to ensure product integrity throughout the supply chain.

Purpose of the Study:

To develop a novel, sensitive defrost sensor using self-assembled peptide-based hydrogels.
To utilize hydrogel turbidity as a reliable indicator of temperature excursions.
To create a stable, irreversible, and tunable sensor for monitoring the pharmaceutical cold chain.

Main Methods:

Synthesis and characterization of self-assembled peptide-based hydrogels.
Investigation of hydrogel gelation kinetics under varying temperature conditions.
Turbidity measurements to correlate structural changes with temperature exposure.
Evaluation of sensor stability, irreversibility, and tunability for specific temperature ranges.

Main Results:

Peptide-based hydrogels were successfully fabricated into sensitive defrost sensors.
Hydrogel turbidity changes correlated directly with temperature fluctuations, serving as a reliable marker.
The developed sensor demonstrated long-term storage stability at room temperature.
The sensor provided irreversible indication of thawing events and could be tuned for specific temperature thresholds.

Conclusions:

Self-assembled peptide-based hydrogels offer a promising platform for developing advanced defrost sensors.
The turbidity-based sensor effectively monitors temperature excursions in the pharmaceutical cold chain.
This technology enhances the reliability and safety of transporting and storing sensitive pharmaceutical products.