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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

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Updated: Aug 18, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

A Novel and Efficient Platform for Discovering Noncanonical Quorum-Quenching Proteins.

Jinxing Liao¹, Zihan Li¹, Dan Xiong¹

¹College of Plant Protection, Laboratory of Plant Immunity, Key Laboratory of Integrated Management of Crop Diseases and Pests, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.

Microbiology Spectrum

|December 8, 2022

Summary

This summary is machine-generated.

Researchers discovered a new method to find noncanonical quorum-quenching (QQ) proteins that block bacterial communication. These proteins, unlike previous ones, do not degrade signals but interfere with their production, offering new anti-infective drug potential.

Keywords:

AHL AHL synthase Lysobacter noncanonical quorum-quenching protein quorum quenching quorum sensing

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In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

Published on: September 2, 2019

Area of Science:

Microbiology
Biochemistry
Genomics

Background:

Quorum sensing (QS) is a bacterial communication system using acyl-homoserine lactones (AHLs).
Canonical quorum quenching (QQ) proteins degrade AHLs to control bacterial infections.
A need exists for novel QQ strategies to combat antibiotic resistance.

Purpose of the Study:

To develop a novel platform for discovering noncanonical AHL quorum-quenching proteins.
To identify and characterize new QQ proteins that do not degrade AHLs.

Main Methods:

Comparative genomics to identify candidate genes in non-AHL-producing bacteria.
Functional screening of candidate genes in recombinant AHL-producing E. coli.
Biochemical assays to characterize protein interactions and function.

Main Results:

A novel platform successfully identified noncanonical QQ proteins.
The glycosyltransferase-like protein Le4759 from Lysobacter was identified as a noncanonical QQ protein.
Le4759 blocks AHL production by interacting with AHL synthases, not by degrading AHLs.

Conclusions:

The developed platform enables the discovery of diverse noncanonical QQ proteins.
Noncanonical QQ proteins like Le4759 offer a new approach to control bacterial infections.
These findings hold promise for developing next-generation anti-infective drugs against antibiotic-resistant bacteria.