Breast cancer pharmacogenetics: a systematic review

Area of Science:

• Pharmacogenetics
• Oncology
• Genetics

Background:

• Breast cancer is the most common cancer globally as of 2020.
• Treatment efficacy is influenced by genetic polymorphisms and patient ethnicity.
• Pharmacogenetics offers insights into personalized treatment strategies.

Approach:

• A systematic review was conducted to assess relevant genes in breast cancer treatment pathways.
• Polymorphism frequencies and ethnic/continental representation in existing literature were analyzed.
• The study focused on evaluating treatment response from a pharmacogenetic viewpoint.

Key Points:

• Identified associations between genetic polymorphisms and breast cancer treatment response.
• Highlighted ethnic and continental disparities in pharmacogenetic research.
• Revealed gaps in current literature regarding diverse population representation.

Conclusions:

• Personalized breast cancer treatments can be developed based on genetic and ethnic factors.
• Future research should address identified gaps to improve treatment personalization.
• The goal is to achieve more effective, safer, and universally accessible breast cancer therapies.