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Elevated serum Meteorin-like levels in patients with hyperthyroidism.
Xiaohui Wen1, Xiaoyu Ding2, Xiaona Chang2
1Department of Otolaryngology Head & Neck Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
BMC Endocrine Disorders
|December 8, 2022
Summary
Serum Meteorin-like (Metrnl) levels are elevated in hyperthyroid patients. Higher Metrnl levels are independently associated with hyperthyroidism, suggesting a potential role in the condition.
Area of Science:
- Endocrinology
- Metabolic research
- Adipokine signaling
Background:
- Meteorin-like (Metrnl) is an adipomyokine regulating energy homeostasis.
- Both Metrnl and thyroid hormones increase energy expenditure and adipose tissue browning.
Purpose of the Study:
- To investigate serum Metrnl levels in hyperthyroid patients.
- To determine the association between serum Metrnl levels and hyperthyroidism.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum Metrnl levels.
- Study included 88 untreated hyperthyroid patients and 100 healthy controls.
Main Results:
- Serum Metrnl levels were significantly higher in hyperthyroid patients versus controls.
- Metrnl levels showed independent associations with FT3, FT4, and TSH.
- Elevated Metrnl was significantly linked to hyperthyroidism, even after adjusting for confounders.
Conclusions:
- Serum Metrnl levels are elevated in individuals with hyperthyroidism.
- Metrnl is independently associated with hyperthyroidism, indicating its potential involvement.
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