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Therapies for Type 1 Diabetes: Is a Cure Possible?

Neihenuo Chuzho1,2, Neetu Mishra2, Nikhil Tandon3

  • 1ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.

Current Diabetes Reviews
|December 8, 2022
PubMed

Insights

This review explores emerging type 1 diabetes (T1D) treatments beyond insulin, including cell replacement, immunotherapy, and artificial pancreas technologies. It examines challenges and future potential for T1D management and cures.

Area of Science:

  • Endocrinology and Metabolism
  • Regenerative Medicine
  • Immunology

Background:

  • Current type 1 diabetes (T1D) management relies on exogenous insulin to control blood glucose.
  • Significant research is directed towards predicting, preventing, and curing T1D.
  • Novel therapeutic strategies are emerging to address the limitations of conventional T1D treatment.

Approach:

  • This review synthesizes current research on advanced T1D therapies.
  • It examines β-cell replacement, immunotherapy, gene and stem cell therapies, and artificial pancreas systems.
  • Non-traditional alternative therapies are also considered.

Key Points:

  • Islet transplantation and stem cell therapies aim for β-cell restoration.
  • Immunotherapies target the autoimmune destruction of pancreatic cells.
  • Artificial pancreas technology offers automated glucose control.
  • Non-traditional therapies are gaining traction as complementary options.

Conclusions:

  • Multiple promising therapeutic avenues are under development for type 1 diabetes.
  • Significant challenges remain in efficacy, safety, and accessibility for these advanced treatments.
  • These innovative strategies hold the potential to revolutionize type 1 diabetes care and offer curative possibilities.
Keywords:
Type 1 diabetesalternative therapyartificial pancreascurative therapyencapsulationimmunotherapyinsulinislet transplantationstem cellsβ-cell

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