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Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?
Motahareh Khosrojerdi1, Eric Gumpricht2, Tannaz Jamialahmadi3,4
1Department of Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:
Oral lichen planus (OLP) is a chronic mucocutaneous, immunological disease that occurs more frequently in the buccal mucosa of middle-aged female patients. OLP's standard treatment is topical or systemic corticosteroids. Due to corticosteroids' numerous potential side effects, there is an effort to find an alternative treatment. One alternative treatment is curcumin. Several studies have investigated the effectiveness and safety of curcumin in OLP patients. In this review, we summarized the literature focusing on the effectiveness and safety of curcumin in OLP patients. Our review of clinical trials revealed that either 6000 mg/day curcumin, 80 mg/day nano-curcumin, or 1% curcumin oral gel 6 times/day offered benefits in the treatment of OLP.
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