The Clinical Outcomes of COVID-19 in Patients on Warfarin: A Propensity Score Matching Study

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Mustafa Oğuz1, Tayyar Akbulut1, Faysal Saylık1

  • 1Department of Cardiology, Sultan Abdülhamid Han Training and Research Hospital, İstanbul, Turkey.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|December 8, 2022
PubMed

Insights

Warfarin, a potent oral anticoagulant, showed clinical benefits in COVID-19 patients. This study suggests potent anticoagulation is crucial for treating COVID-19, reducing mortality and intensive care unit admissions.

Area of Science:

  • Internal Medicine
  • Cardiology
  • Infectious Diseases

Background:

  • COVID-19 is linked to vascular thrombosis in critically ill patients.
  • The efficacy of warfarin in COVID-19 patients remains understudied.
  • This research investigates the clinical benefits of warfarin in COVID-19 management.

Purpose of the Study:

  • To evaluate the clinical benefit of warfarin in COVID-19 patients.
  • To compare outcomes between COVID-19 patients on warfarin and those not on warfarin.
  • To assess warfarin's impact on mortality, hospitalization, and ICU admission.

Main Methods:

  • Retrospective cohort study of COVID-19 patients across three Turkish centers (April 2020-April 2021).
  • Patients categorized based on warfarin use.
  • Propensity score matching analysis employed to compare outcomes.

Main Results:

  • Matched analysis of 84 pairs revealed significant differences between warfarin and control groups.
  • Warfarin group showed lower ICU admission rates (14.3% vs. 33.3%) and shorter hospital stays (7.1 vs. 14.1 days).
  • The warfarin group experienced a substantially lower mortality rate (7.1% vs. 27.4%) and reduced in-hospital death incidence.

Conclusions:

  • Warfarin therapy demonstrates potential clinical benefits for COVID-19 patients.
  • Findings underscore the importance of potent anticoagulation in COVID-19 treatment.
  • Further research may confirm warfarin's role in improving COVID-19 outcomes.
Abstract

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