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Hematological disorders in preterm newborns born to mothers with pregnancy-induced hypertension

Karina L Arce-López1, José Iglesias-Leboreiro1,2, Isabel Bernárdez-Zapata1,2

  • 1Facultad Mexicana de Medicina, Universidad La Salle.

Boletin Medico Del Hospital Infantil De Mexico
|December 8, 2022
PubMed

Insights

Hematological alterations are common in preterm infants born to mothers with pregnancy-induced hypertension (PIH). These changes, including lymphopenia and monocytosis, do not correlate with maternal condition severity, necessitating comprehensive neonatal blood evaluations.

Area of Science:

  • Neonatal Hematology
  • Perinatal Medicine
  • Maternal-Fetal Medicine

Background:

  • Pregnancy-induced hypertension (PIH) may impact fetal development through hematopoiesis.
  • This study investigates common hematological changes in preterm infants born to mothers with PIH.

Approach:

  • Cross-sectional study of 130 preterm infants' hemograms.
  • Analysis included infants from mothers with PIH, preeclampsia, and HELLP syndrome.
  • Statistical analysis adjusted for gestational age, using classical and Bayesian methods.

Key Points:

  • Anemia was rare (1.2%).
  • Frequent findings included lymphopenia (56.2%) and monocytosis (38.5%).
  • Thrombocytopenia occurred in 12.5% of infants.

Conclusions:

  • Hematological alterations are frequent in neonates exposed to PIH in utero.
  • No distinct pattern of alterations correlated with maternal PIH severity was observed.
  • Full hematological assessment is recommended for these preterm neonates.
Abstract

Keywords:
HemogramHemogramaHipertensión gestacionalNeonatoPlaquetopeniaPregnancy-induced hypertensionPrematuroPreterm newbornThrombocytopenia

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