Related Experiment Video
Updated: Aug 18, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
DOSE CALCULATION OF PROTON THERAPY BASED ON MONTE CARLO AND EMPIRICAL FORMULA
1School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui Province 230026.
Abstract:
In this work, we used the Monte Carlo-based TOPAS simulation software to calculate the ambient dose equivalents and annual effective dose due to the secondary neutron field produced in proton therapy, also we introduced a USTC phantom to access the organ equivalent dose. The ambient dose equivalent and annual effective dose were calculated in several positions of interest inside and outside the facility. The simulation results were compared qualitatively to the results of the Empirical Formula, showing that the Empirical Formula calculations overestimated the dose, 28.95 times higher than the MC simulations, on average, which would lead to over shielding. In addition, the highest equivalent dose rate of a single radiation-sensitive organ simulated by TOPAS was 1.50 × 10-9 mSv/a for the eye lens, 2.36 × 10-3 mSv/a for limbs and 1.01 × 10-3 mSv/a for skin, which also meets the limits. Therefore, MC simulation has great advantages in shielding design and safety evaluation. And this work presents a new method to calculate the dose, introducing a more anthropogenic phantom can get more realistic results.
More Related Videos
07:57Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
06:20Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Related Concept Videos
Experimental Determination of Chemical Formula
Biological Effects of Radiation
Rational Dosage Regimen: Maintenance Dose and Loading Dose
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
Dose-Response Relationship: Overview
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Dose-Response Relationship: Potency and Efficacy