Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

578
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
578
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

633
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
633
Hypodermis01:02

Hypodermis

4.9K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.9K
Hypersensitivities01:30

Hypersensitivities

895
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
895
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

35
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
35
Allergic Drug Reactions01:27

Allergic Drug Reactions

925
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
925

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alteration of individual morphological brain networks in preschool children with autism spectrum disorder.

Brain imaging and behavior·2026
Same author

Layered Copper-Anthraquinone Coordination Polymer Cathode Leveraging Dual-Redox Sites and Facilitated Ion Diffusion for High-Performance Lithium-Ion Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Altered static and dynamic functional network connectivity in Parkinson's disease: A multisite functional magnetic resonance imaging study.

IBRO neuroscience reports·2026
Same author

The effectiveness of a plant-based milk with fermented brown rice on constipation symptoms via gut microbiota modulation: a double-blind randomized controlled trial.

European journal of nutrition·2026
Same author

Self-Adaptive AdamW-Guided Optimization: A Learning-Driven Metaheuristic for Solving Complex Real-World Engineering Problems.

Entropy (Basel, Switzerland)·2026
Same author

Liver transplantation promotes early neural reorganization in minimal hepatic encephalopathy: a longitudinal resting state fMRI study.

Metabolic brain disease·2026

Related Experiment Video

Updated: Aug 18, 2025

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

4.1K

The interaction between obesity and visceral hypersensitivity.

Wu Yanping1, Xuefen Gao1, Yizun Cheng1

  • 1Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Journal of Gastroenterology and Hepatology
|December 8, 2022
PubMed
Summary

Obesity links to irritable bowel syndrome (IBS) via gut inflammation, microbiota changes, vitamin D deficiency, and brain-gut signals. These factors increase visceral hypersensitivity, a key IBS symptom.

Keywords:
inflammationirritable bowel syndromemicrobiotaobesityvitamin D

More Related Videos

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.4K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

920

Related Experiment Videos

Last Updated: Aug 18, 2025

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

4.1K
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.4K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

920

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Neuroscience

Background:

  • Obesity is a global health issue linked to chronic diseases.
  • Obesity may contribute to visceral hypersensitivity and irritable bowel syndrome (IBS).

Purpose of the Study:

  • To explore the multifaceted relationship between obesity and visceral hypersensitivity.
  • To elucidate the mechanisms connecting obesity to IBS symptoms.

Main Methods:

  • Review of scientific literature on obesity, gut physiology, and neuroscience.
  • Analysis of inflammatory mediators from adipose tissue.
  • Investigation of gut microbiota and metabolite roles.
  • Examination of vitamin D's impact on gut barrier function.
  • Exploration of brain-gut axis involvement.

Main Results:

  • Adipose tissue releases inflammatory mediators, increasing intestinal permeability and nerve sensitivity.
  • Obesity-associated gut microbiota alterations and their metabolites heighten colonic sensitivity.
  • Vitamin D deficiency exacerbates fat accumulation and compromises intestinal barrier integrity.
  • The brain-gut axis serves as a pathway linking obesity to visceral hypersensitivity.

Conclusions:

  • Obesity contributes to visceral hypersensitivity through several interconnected pathways.
  • Understanding these mechanisms is crucial for managing IBS in obese individuals.