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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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Precursor-Directed Synthesis of Apoptosis-Initiating N-Hydroxyalkyl Phenylbenzoisoquinolindione Alkaloids

Yu Chen1,2, Hans-Martin Dahse3, Christian Paetz1

  • 1Max-Planck-Institute for Chemical Ecology, NMR/Biosynthesis Group, Hans-Knöll-Straße 8, 07745, Jena, Germany.

Chemistryopen
|December 8, 2022
PubMed

Keywords:
antiproliferative effectapoptosiscytotoxicityphenylbenzoisoquinolindioneprecursor-directed synthesis

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