Cadmium-Doped and Pincer Ligand-Modified Gold Nanocluster for Catalytic KA² Reaction

A gold nanocluster Au₁₇ Cd₂ (PNP)₂ (SR)₁₂ (PNP=2,6-bis(diphenylphosphinomethyl)pyridine, SR=4-MeOPhS) consisting of an icosahedral Au₁₃ kernel, two Au₂ CdS₆ staple motifs, and two PNP pincer ligands has been designed, synthesized and well characterized. This cadmium and PNP pincer ligand co-modified gold nanocluster showed high catalytic efficiency in the KA² reaction, featuring high TON, mild reaction conditions, broad substrate scope as well as catalyst recyclability. Comparison of the catalytic performance between Au₁₇ Cd₂ (PNP)₂ (SR)₁₂ and the structurally similar single cadmium (or PNP) modified gold nanoclusters demonstrates that the co-existence of the cadmium and PNP on the surface is crucial for the high catalytic activity of the gold nanocluster. This work would be enlightening for developing efficient catalysts for cascade reactions and discovering the catalytic potential of metal nanoclusters in organic transformations.