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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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T-box transcription factor 2 mediates antitumor immune response in cutaneous squamous cell carcinoma by regulating

Xu Wang1, Zhi Li1, Yadi Sun2

  • 1Department of Dermatology, the Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|December 8, 2022
PubMed
Abstract

Insights

T-box transcription factor 2 (TBX2) promotes cutaneous squamous cell carcinoma (CSCC) progression by upregulating programmed death ligand 1 (PD-L1) via interferon regulatory factor 1 (IRF1). This suggests TBX2 as a potential prognostic marker and therapeutic target for CSCC immunotherapy.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cutaneous squamous cell carcinoma (CSCC) presents limited treatment options for metastatic cases.
  • The role of T-box transcription factor 2 (TBX2) in CSCC pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the function of TBX2 in CSCC.
  • To explore the relationship between TBX2 and programmed death ligand 1 (PD-L1) expression in CSCC.

Main Methods:

  • Assessed TBX2 expression in CSCC samples and cell lines.
  • Analyzed PD-L1 expression in human CSCC samples.
  • Utilized TBX2 loss-of-function and overexpression in SCC13 cells to determine PD-L1 regulation.

Main Results:

  • TBX2 expression positively correlated with CSCC stage and was significantly higher in tumor cell lines.
  • PD-L1 expression was upregulated in CSCC and positively correlated with TBX2 levels.
  • TBX2 mediated PD-L1 expression through interferon regulatory factor 1 (IRF1), independent of IFNγ signaling.

Conclusions:

  • TBX2 regulates the antitumor immune response in CSCC by modulating PD-L1 via IRF1.
  • TBX2 shows potential as a prognostic biomarker for CSCC.
  • TBX2 may serve as a synergistic therapeutic target for PD-1 immunotherapy in CSCC.
Keywords:
PD-L1TBX2cutaneous squamous cell carcinomaimmunotherapy

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