Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

187
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
187
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

145
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
145
Teratogenicity01:07

Teratogenicity

2.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.6K
Modeling in Therapy01:26

Modeling in Therapy

137
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
137
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

117
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
117
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

56
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
56

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scientists' warning: we must change paradigm for a revolution in toxicology and world food supply.

Environmental sciences Europe·2026
Same author

Effects of Endocrine-Disrupting Chemicals in the Brain: The Example of Neurodevelopment Alterations upon Exposure In Utero to Synthetic Sex Hormones.

Journal of xenobiotics·2025
Same author

In utero exposure to synthetic sex hormones and their multigenerational impact on neurodevelopmental disorders: Endocrine disruptors as neuroendocrine disruptors.

Journal of the neurological sciences·2025
Same author

A Risk Score to Identify Low Bone Mineral Density for Age in Young Patients with Anorexia Nervosa.

Nutrients·2025
Same author

Artificial shrinkage before fresh blastocyst transfer and IVF outcomes: a pilot randomized controlled study.

Reproductive biomedicine online·2024
Same author

Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Aug 18, 2025

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.1K

Diethylstilbestrol and autism.

Marie-Odile Soyer-Gobillard1,2, Laura Gaspari3,4,5, Philippe Courtet6,7

  • 1Univ Sorbonne, Centre National de la Recherche Scientifique (CNRS), Paris, France.

Frontiers in Endocrinology
|December 8, 2022
PubMed
Summary

Diethylstilbestrol (DES) exposure in utero may increase the risk of neurodevelopmental and psychiatric disorders, including Autism Spectrum Disorders (ASD), in exposed individuals and their descendants. Further research is needed to understand these transgenerational effects.

Keywords:
autismdiethylstilbestrolendocrine disruptorsepigeneticspsychiatric disorders

More Related Videos

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

1.8K
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K

Related Experiment Videos

Last Updated: Aug 18, 2025

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.1K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

1.8K
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K

Area of Science:

  • Endocrinology
  • Neuroscience
  • Genetics

Background:

  • Diethylstilbestrol (DES) is a synthetic estrogen linked to reproductive abnormalities.
  • Limited data exists on the neurodevelopmental and psychiatric effects of in utero DES exposure.
  • Autism Spectrum Disorders (ASD) are a key concern in this context.

Purpose of the Study:

  • To review current evidence on the link between in utero DES exposure and psychiatric disorders, particularly ASD.
  • To highlight the potential transgenerational impact of endocrine disruptors like DES.
  • To emphasize the need for precautionary measures regarding synthetic hormone use.

Main Methods:

  • Review of epidemiological studies and molecular research on DES and other synthetic estrogens/progestogens.
  • Analysis of cohort studies examining psychiatric disorders in DES-exposed populations.
  • Examination of epigenetic modifications in genes related to neurodevelopment.

Main Results:

  • Epidemiological studies report increased rates of depression, bipolar disorder, schizophrenia, and suicide attempts in DES-exposed individuals.
  • Few studies have documented ASD in children exposed to DES in utero.
  • Molecular studies show transgenerational disease induction and epigenetic changes (DNA methylation) at neurodevelopmental genes (ZFP57, ADAMTS9).

Conclusions:

  • In utero exposure to DES and similar endocrine disruptors may contribute to the pathogenesis of psychiatric disorders, including ASD.
  • Evidence suggests a transgenerational epigenetic impact of DES exposure.
  • Women should exercise extreme caution with synthetic hormones due to potential risks to current and future generations.