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Updated: Aug 18, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Cross-continental collaboration for understanding postpartum major depression with psychotic features
Mary Kimmel1, Harish Thippeswamy2, Astrid Kamperman3
1Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States.
Purpose:
Assess postpartum depression and psychotic symptoms from three continents.
Methods:
Compare numbers of women with depression and psychotic symptoms, mania with or without psychotic features, or transient non-affective psychosis and medication choice.
Results:
The prevalence of postpartum depression and psychosis and treatment choice differed at each site.
Conclusions:
Best treatment for postpartum depression with psychotic features has not been established yet. Cross-continental collaboration with similar assessments holds promise to develop best practices for these high risk mother-infant dyads.
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