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Related Concept Videos

Clinical Trials01:16

Clinical Trials

6.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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The Scientific Method in Nursing Process01:18

The Scientific Method in Nursing Process

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The scientific method provides the foundation for any research. It is the most reliable and objective of all forms of gaining knowledge and guides in applying research-based evidence in practice and conducting future research.
When using research findings to change practice, one must understand the process used to guide a study. The scientific method is a systematic, step-by-step process that supports the data's validity, reliability, and generalizability. As a result, findings can be...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Case Studies01:22

Case Studies

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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Updated: Aug 18, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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Methodology for clinical research.

Aysha Karim Kiani1,2, Zakira Naureen2,3, Derek Pheby4

  • 1Allama Iqbal Open University, Islamabad, Pakistan.

Journal of Preventive Medicine and Hygiene
|December 8, 2022
PubMed
Summary
This summary is machine-generated.

Understanding clinical research methodology is essential for reliable results. This review details study types, planning, and execution for effective medical research.

Keywords:
BiasClinical researchExperimental studiesObservational studiesStudy design

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Area of Science:

  • Medical Research Methodology
  • Clinical Study Design

Background:

  • Clinical research demands systematic planning, execution, and sampling for valid results.
  • Inappropriate study type selection leads to flawed methodology, which cannot be corrected.
  • Medical research encompasses primary (data collection) and secondary (data analysis) research.

Purpose of the Study:

  • To review various aspects of clinical research methodology.
  • To describe crucial conceptual and executive stages of research.
  • To emphasize the importance of understanding different clinical research methods.

Main Methods:

  • The review covers different types of clinical studies, including descriptive, analytical, observational, and experimental designs.
  • It discusses factors influencing methodology deployment, such as objectives, population, and sampling.
  • Pre-clinical studies are highlighted as foundational to clinical trials.

Main Results:

  • A thorough understanding of research methodology is vital for successful clinical research.
  • Proper study type selection and planning are critical to avoid methodological errors.
  • Effective methodology ensures reliable and validated results that advance medical knowledge.

Conclusions:

  • Understanding diverse clinical research methodologies is paramount for researchers.
  • Systematic planning and appropriate study design are key to generating high-quality clinical data.
  • This review provides insights into the essential steps for conducting robust clinical research.