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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Comparing Copy Number Variations and SNPs02:26

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

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Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

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Polymorphisms, diet and nutrigenomics.

Aysha Karim Kiani1, Gabriele Bonetti2, Kevin Donato1

  • 1MAGI EUREGIO, Bolzano, Italy.

Journal of Preventive Medicine and Hygiene
|December 8, 2022
PubMed
Summary
This summary is machine-generated.

Nutrigenomics explores how nutrients interact with your unique genetic makeup to influence health and prevent disease. Understanding these gene-nutrient interactions can personalize nutrition for better health outcomes and weight management.

Keywords:
MetabolomicsNutrigeneticsNutrigenomicsPhysical activityPrecision nutrition

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Area of Science:

  • Nutrigenomics
  • Nutrigenetics
  • Genomic Science

Background:

  • Individual genetic blueprints dictate unique nutritional needs.
  • Bioactive food components and nutrients influence gene expression.
  • Genomic diversity impacts nutrient bioavailability and metabolism across ethnic groups.

Purpose of the Study:

  • To analyze gene-nutrient interactions (nutrigenetics).
  • To develop personalized nutritional recommendations for optimal health and disease prevention.
  • To explore the role of genetic polymorphisms in weight management.

Main Methods:

  • Integrates nutrition, bioinformatics, genomics, molecular biology, molecular medicine, and epidemiology.
  • Utilizes epigenetics, transcriptomics, proteomics, and metabolomics to study gene-nutrient interactions.
  • Analyzes genetic polymorphisms to understand gene-nutrient relationships.

Main Results:

  • Nutrients modulate gene expression, influencing health and metabolism.
  • Genetic testing can aid in understanding gene-nutrient interactions for weight loss.
  • Nutrigenomics offers insights into personalized dietary strategies.

Conclusions:

  • Nutrigenomics provides a framework for personalized nutrition based on individual genetic profiles.
  • Optimizing diet through nutrigenomics can lead to effective long-term lifestyle changes.
  • Personalized nutrition holds potential for weight management and improved quality of life.