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Infectious native aortic aneurysm with negative blood cultures: do not forget the pneumococcal urinary antigen test!

Marie Dubert1,2, Lucie Derycke3, Anne-Laure Bidaud1,4

  • 1Université Paris Cité, Paris, France.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|December 8, 2022
PubMed

Insights

Pneumococcal infectious native aortic aneurysms (INAA) are rare infections. A urinary antigen test aided diagnosis in two cases with negative blood cultures, improving patient outcomes.

Area of Science:

  • Infectious diseases
  • Cardiovascular medicine
  • Microbiology

Background:

  • Infectious native aortic aneurysms (INAA) are uncommon yet critical conditions.
  • Timely microbiological diagnosis is vital for effective treatment and reduced surgical risks.
  • Blood cultures are frequently negative in INAA cases, complicating diagnosis.

Observation:

  • Two cases of pneumococcal INAA presented with negative blood cultures.
  • The pneumococcal urinary antigen test was utilized for diagnosis in both instances.
  • This diagnostic approach facilitated prompt identification of the causative pathogen.

Findings:

  • The pneumococcal urinary antigen test successfully identified Streptococcus pneumoniae in both INAA cases.
  • This diagnostic method proved effective despite negative blood cultures.
  • Early identification enabled targeted antimicrobial therapy.

Implications:

  • The pneumococcal urinary antigen test is a valuable tool for diagnosing INAA when blood cultures are uninformative.
  • This diagnostic strategy can expedite appropriate treatment for pneumococcal INAA.
  • Improved diagnostic methods for INAA can lead to better patient prognoses and reduced mortality.
Keywords:
Streptococcus pneumoniaeAortitisbacteriologyclinical microbiologypatholgy

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