Development in Fluorescent OFF-ON Probes Based on Cu²⁺ Promoted Hydrolysis Reaction of the Picolinate Moiety

Anions and cations have a key role in our normal life. Cu²⁺ ion is a crucial trace element accountable for the part of several cellular enzymes and proteins, including cytochrome c oxidase, dopamine monooxygenase, Cu/Zn superoxide dismutase, and ceruloplasmin. WHO has found the extreme acceptable level of Cu²⁺ ions in drinking water is up to 2.0 ppm. Excess use of Cu²⁺ ions is associated with various human genetic disorders. Thus, the visualization of Cu²⁺ ions to avoid its toxic effects in chemical and biological systems is significant. In this review we have summarized sensors based on catalytic hydrolysis of picolinate to detect Cu²⁺ ions. The sensors based on hydrolysis of picolinate are very selective as compared to the other sensors for Cu²⁺ ions detection. We have focused on describing the structure, spectral properties, detection limits, and bioimaging model of the sensors.