Related Experiment Video
Updated: Aug 18, 2025
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
A New Ceramide from Cissus Aralioides Baker (Vitaceae) and its Antimicrobial Activity
Romeo Desire T Nago1, James D Simo Mpetga1, Jean-De-Dieu Tamokou2
1Natural Products Chemistry Research Unit, Chemistry Department, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Abstract:
Purification through repeated column chromatography over silica gel and Sephadex LH-20 of the ethanol extract of the stems of Cissus aralioides (Baker) Planch. resulted in the isolation of a new ceramide, aralioidamide A (1), along with five known compounds (2-6). Their structures were determined by the extensive analyses of their spectroscopic (1D and 2D NMR) and spectrometric data, and comparison with those reported in the literature. Aralioidamide A (1) displayed weak antibacterial activity (MIC=256 μg/mL) against Bacillus subtilis, Staphylococcus aureus and Shigella flexneri and was inactive (MIC>256 μg/mL) against the tested fungi.
Related Concept Videos
01:28Antimicrobial Effectiveness
01:18Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
01:28Assembly of the Lipid Bilayer in the ER
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...