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Effect of dexpanthenol on wound healing in penile fracture model: An experimental study
Veli M Yazar1, Omer G Doluoglu1, Berat C Ozgur1
1Department of Urology. Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey.
Objectives:
In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue.
Materials And Methods:
Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Group S, Group LD, and Group SD. In Group B, the incision was not repaired and left to secondary healing. In Group S, the incision line was repaired with 5/0 polyglactin suture. In Group LD, 0.25 mg/kg dexpanthenol was applied subcutaneously below the repaired wound region once a day during 14 days. In Group SD, 500 mg dexpanthenol was applied intraperitoneally once a day during 14 days.
Results:
No fibrosis was observed in 8 (80%) rats in group SD. Fibrosis rates were significantly lower in Group SD compared to Group B, Group S, and Group LD (p = 0.013, p = 0.005, and p = 0.003, respectively).
Conclusion:
Systemic dexpanthenol administration significantly decreased fibrosis in penile fracture model on rats.
