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Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care
Edwin Cuppen1,2, Olivier Elemento3, Richard Rosenquist4,5
1Hartwig Medical Foundation, Amsterdam, the Netherlands.
JCO Precision Oncology
|December 8, 2022
Summary
Whole-genome and transcriptome sequencing (WGTS) offers comprehensive cancer diagnostics and treatment selection. Overcoming implementation barriers will enable its widespread adoption, transforming oncology care.
Area of Science:
- Genomic Medicine
- Cancer Genomics
- Precision Oncology
Background:
- Whole-genome and transcriptome sequencing (WGTS) represents a significant advancement in cancer diagnostics.
- Current oncology molecular testing often involves multiple, sequential tests, which WGTS can consolidate.
- Widespread adoption of WGTS in healthcare systems is currently limited despite its potential.
Approach:
- This review addresses barriers to integrating WGTS into clinical practice.
- It examines the utility of WGTS across various cancer types.
- Key considerations such as cost-effectiveness, affordability, and regulatory aspects are discussed.
Key Points:
- WGTS is a comprehensive diagnostic tool suitable for numerous cancer types.
- It can effectively replace existing, fragmented molecular testing strategies.
- Decreasing costs and expanding biomarker discovery support WGTS implementation.
Conclusions:
- WGTS has the potential to revolutionize cancer diagnosis and treatment selection.
- Addressing practical, regulatory, and financial challenges is crucial for its integration.
- Successful implementation of WGTS will enhance precision oncology care globally.
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